Palladium coupling precatalysts - PdL2X2

Johnson Matthey offers a selection of bis-phosphine palladium halide pre-catalysts for basic cross coupling applications. The PdL2X2 precatalysts accommodate many widely used tri-aryl, tri-alkyl and bidentate phosphine ligands useful for a range of cross coupling transformations such as Suzuki-Miyaura couplings, Kumada/Negishi couplings, Sonogashira couplings, Heck reactions, Miyaura borylations and carbonylative coupling reactions (1,2). These palladium coupling precatalysts are activated most effectively under strongly basic or reducing conditions (3).

Palladium coupling precatalysts � PdL2X2 products

Pd-100: PdCl2(PPH3)2
PdCl2(PPh3)2
Product number: Pd-100
CAS number: 13965-03-2
Mol weight: 701.90
Reaction type: Suzuki coupling, Sonogashira coupling
 
Pd-106: PdCl2(»å±è±è´Ú)·°ä±á2Cl2
PdCl2(»å±è±è´Ú)·°ä±á2Cl2
Product number: Pd-106
CAS number: 95464-05-4
Mol weight: 816.64
Reaction type: Suzuki coupling, Miyaura borylation, Negishi coupling, Kumada coupling
Pd-107: PdCl2(»å±è±è´Ú)·(°ä±á3)2CO
PdCl2(»å±è±è´Ú)·(°ä±á3)2CO
Product number: Pd-107
CAS number: 851232-71-8
Mol weight: 789.79
Reaction type: Suzuki coupling, Miyaura borylation, Negishi coupling, Kumada coupling
Pd-114: PdCl2 [P(Cy)3]2
PdCl2(Cy3P)2
Product number: Pd-114
CAS number: 29934-17-6
Mol weight: 738.19
Reaction type: Suzuki coupling, Sonogashira coupling, Heck, Buchwald-Hartwig amination
Pd-117: PdCl2 DPEPhos
PdCl2 DPEPhos
Product number: Pd-117
CAS number: 205319-06-8
Mol weight: 715.89
Reaction type: Suzuki coupling, Miyaura borylation, carbonylative coupling
Pd-118: PdCl2 (dtbpf)
PdCl2(dtbpf)
Product number: Pd-118
CAS number: 95408-45-0
Mol weight: 651.75
Reaction type: Suzuki coupling, Negishi coupling, Kumada, Buchwald-Hartwig amination
Pd-119: PdCl2 (dippf)
PdCl2 (dippf)
Product number: Pd-119
CAS number: 215788-65-1
Mol weight: 595.65
Reaction type: Suzuki coupling, Miyaura borylation, Negishi, Kumada, Buchwald-Hartwig 
Pd-122: PdCl2 [P(tBu)2Ph]2
PdCl2 [P(tBu)2Ph]2
Product number: Pd-122
CAS number: 34409-44-4
Mol weight: 621.95
Reaction type: Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Heck 
Pd-126: PdCl2(dppp)
PdCl2(dppp)
Product number: Pd-126
CAS number: 59831-02-6
Mol weight: 589.78
Reaction type: Suzuki coupling, Negishi coupling, Kumada coupling, Heck coupling
Pd-127: PdCl2(dcypf)
PdCl2(dcypf)
Product number: Pd-127
CAS number: 917511-90-1
Mol weight: 755.90
Reaction type: Suzuki coupling, Negishi coupling, Kumada coupling, Buchwald-Hartwig
Pd-132: PdCl2 (Amphos)2
PdCl2 (Amphos)2
Product number: Pd-132
CAS number: 887919-35-9
Mol weight: 708.08
Reaction type: Suzuki coupling, Buchwald-Hartwig Amination
 
Pd-133: PdCl2 (dcypp)
PdCl2 (dcypp)
Product number: Pd-133
CAS number: 1041005-52-0
Mol weight: 613.97
Reaction type: Suzuki coupling, Negishi coupling, Kumada coupling, Buchwald-Hartwig
Pd-134: PdCl2 XantPhos
PdCl2 (XantPhos)
Product number: Pd-134
CAS number: 205319-10-4
Mol weight: 755.96
Reaction type: Suzuki coupling, Heck coupling, Buchwald-Hartwig, C-H coupling
Pd-140: PdCl2 (DCEPhos)
PdCl2 (DCEPhos)
Product number: Pd-140
CAS number: 1265140-81-5
Mol weight: 35.00
Reaction type: Suzuki coupling, carbonylative coupling
 
Pd-166: PdCl2 [P(tBu)(Cy)2]2
PdCl2 [P(tBu)(Cy)2]2
Product number: Pd-166
CAS number: 104889-13-6
Mol weight: 686.12
Reaction type: Suzuki coupling, Buchwald-Hartwig, Sonogashira coupling, Heck coupling

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References: 

  1.     1. Rayadurgam, J.; Sana, S.; Sasikumar, M.; Gu, Q. Org. Chem. Front. 2021, 8, 384 â€� 414 
  2.     2. Wu, X.; Neumann, H.; Beller, M. Chem. Rev. 2013, 113, 1 â€� 35 
  3.     3. Proutiere, F.; Aufiero, M.; Schoenebeck, F. J. Am. Chem. Soc. 2012, 134, 606 â€� 612